Meg Ryan was the undisputed queen of romantic comedy. Then one movie ruined it all.

Meg Ryan never planned on being a famous movie star.

The actress, who is best known for her roles in When Harry Met Sally, You’ve Got Mail, and Sleepless in Seattle, was studying journalism at New York University when she stumbled into acting.

In the hopes of earning some extra cash, Ryan starred in the soap opera, As the World Turns, as well as a number of television commercials.

Watch the trailer for When Harry Met Sally below. Post continues after video.

But as the film and television roles started flowing in, the actress soon dropped out of college, choosing to pursue what had started as a mere side hustle.

In the years that followed, Meg Ryan quickly cemented herself as the romantic comedy queen.

Following small roles in Top Gun, Innerspace, and Flesh and Bone, Ryan had her first leading breakout role in Rob Reiner’s 1989 romantic comedy, When Harry Met Sally, starring alongside Billy Crystal and Carrie Fisher.

Written by Nora Ephron, the iconic film earned Ryan a Golden Globe nomination.

After appearing alongside Tom Hanks in Joe Versus the Volcano, which was a commercial disappointment, Ryan starred alongside Hanks for the second time in Sleepless In Seattle.